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Or different tests were summed to calculate the average and standard error. The overall predictive accuracy and auc values of the different hcc classifiers, which were constructed with the 10 upregulated hub genes (classifier 1), 7 downregulated hub genes (classifier 2) and 27 differentially expressed hub genes (classifier 3), on the chen_liver and wurmbach_liver test datasets were shown in table 1, respectively. viagra generic version Firstly, the accuracy values of three classifiers on different independent test datasets were 85. 88(92. 71% and the auc values were all more than 0. 92(0. 96. viagra canada online The auc value is an indicator of the efficacy of the assessment system. cheap viagra online An ideal test with perfect discrimination (100% sensitivity and 100% specificity) has an auc of 1. 0, whereas a non-informative prediction has the area 0. 5, indicating that it may be achieved by mere guess. The closer to 1. vision problems caused viagra 0 the auc of a test is, the higher the overall efficacy of the test will be . We found that our hcc classifier had an area approximating 1. 0, suggesting that it had a relatively high ability to identify the true hcc tissues against the different independent test datasets. Secondly, classifier 3 includes more hub genes (27) than classifier 1 (10) and classifier 2 (7), but its performance (acc and auc) was not significantly higher than that of the other two classifiers. Thirdly, classifier 2 includes the smallest number of genes and was not significantly different from other two classifiers in terms of performance, so we chose classifier 2 for further validation. cheap viagra Table 1. no prescription viagra online pharmacy Performance of hcc classifiers on different independent test datasets. Doi:10. 1371/journal. viagra without a doctor prescription Pone. 0022426. T001 download: powerpoint slide | larger image ( png) | original image ( tiff) five-fold cross-validation. generic viagra canada We also used the 5-fold cross-validation protocol to evaluate the performance of our hcc classifier (classifier 2). The resulting roc curves were illustrated in figure 3. viagra 100mg filmtabletten nebenwirkungen Each point on the roc curve denotes the sensitivity and specificity against a set of weights and score threshold. Because the auc is an indicator of the discriminatory power for the classifier, it was also used here to evaluate the predictive efficacy of our hcc classifier. cheap viagra overnight From figure 3, we can find that our hcc classifier had an auc value approximating 1. 0 in all. overnight shipping of generic viagra SUV's at $250/wk with insurance,taxes & unlimited miles.